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SBTI Initiative

Self-Directed Biological Transformation Initiative (SBTI)

Overview

 

This study is a multi-center collaborative effort looking at multiple physical and emotional effects of a 6-day immersion into Ayurvedic mind-body practices. The goal of the Self-Directed Biological Transformation Initiative (SBTI) is to determine whether the practices of Ayurveda, meditation, and yoga can reverse biological markers of aging, alter cellular biology, genomics, and the microbiome. We invited 120 participants into this ground breaking research study in collaboration with Harvard University, the University of California San Francisco, Mount Sinai Hospital, Duke University, Scripps Translational Science Institute, Sanford Burnham Medical Research Institute, and the University of California San Diego. This is the most complete study to date looking at the effects of a whole-systems approach on the mind-body physiology. Included in this study were measurements of psychological wellbeing, markers of inflammation and cell aging, metabolomics, genomics, and changes in microbiome between participants in an Ayurvedic immersion program versus a control group.
 
It has become increasingly recognized that ancient practices for wellbeing, including meditation, yoga, and specific herbs, can improve health and promote longevity. While studies have documented such effects for a variety of individual practices for wellbeing, few studies have taken a more systems biology approach that is simultaneously inclusive of numerous practices. The purpose of this study was to find out more about the health and psychological effects of participation in the Perfect Health course, the Chopra Center’s signature 6-day Mind-Body-Spirit wellness program, as compared to similar individuals who do not participate in the course, and rather participate in solely a vacation week at the Omni La Costa Resort and Spa in Carlsbad, CA.

 

CF-Initiative-SBTI-collaboration

PUBLISHED RESEARCH ARTICLES:

 

SBTI-Complementary-Medicine

Christine Tara Peterson, Joseph Lucas, Lisa St. John-Williams, J. Will Thompson, M. Arthur Moseley, Sheila Patel, Scott N. Peterson, Valencia Porter, Eric E. Schadt, Paul J. Mills, Rudolph E. Tanzi, P. Murali Doraiswamy & Deepak Chopra  (August 2016)

Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI)

Scientific Reports 6, Article number: 32609 (2016)
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SBTI-Complementary-Medicine

Paul J. Mills, Kathleen L. Wilson, Meredith A. Pung, Lizabeth Weiss, Sheila Patel, P. Murali Doraiswamy, Christine Peterson, Valencia Porter, Eric Schadt, Deepak Chopra, and Rudolph E. Tanzi  (June 2016)

The Self-Directed Biological Transformation Initiative and Well-Being

THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE • Volume 00 • Number 0, 2016 • pp. 1–8
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STUDY TESTIMONIALS:

 

HUFFINGTON POST ARTICLES:

 
UPDATES:

Study Co-Chairs

 

deepak
DEEPAK CHOPRA, MD
ss-2011-RudolphTanzi
RUDOLPH TANZI, PhD

The Scientific Research Teams

Three teams of specialists will be studying multiple facets of the effects of medidation on the human body. They include:

GENETIC BIOMARKER AND GENE ACTIVITY

Team Leaders

Rudolph E. Tanzi, PhD and
Eric Schadt, PhD

Will be studying:

– Whole genome sequencing using HiSeq at Illumina

– Whole Genome Gene Expression of Roughly 40,000 Gene Transcripts

– Alzheimer’s-Related Amyloid Beta Protein Species in Plasma by ELISA and MesoScale

– Cytokine Levels in Plasma by MesoScale

– Whole-Genome Epigenetic Changes Using Pacific Bio Systems

– The Plasma Proteome

BLOOD-BASED MARKERS OF CELLULAR AGING

Team Leaders

Nobel Laureate Dr. Elizabeth Blackburn, Elissa Epel, Ph.D., and Paul J. Mills, PhD

Will be studying:

– Telomerase and Telomere Length

– Oxidative Stress

– Inflammation, Cardiovascular Disease and Stress Biomarkers

– Mitochondrial DNA Health

GENERAL PHYSICAL AND HEART HEALTH

Team Leaders

Eric J. Topol, MD and
Steven R. Steinhubl, MD

Will be studying:

– Single lead ECG/ heart rate

– Heart Rate Variability

– Physical Activity

– Sleep Quality

– Respiratory Rate and Depth

– Photoplethysmogram

We are very enthusiastic about this potentially paradigm-shifting study, which can potentially validate self-directed biological transformation and affect the health, quality and length of life for the participants and provide us clues on how to influence the wellbeing of future generations.